Brand  (β version)

PDB ID: 6UI2

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Ligands
Code Name Style Show Link
0KX 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine PoSSuM
GOL Glycerol PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
Code Name Show
FMG 2-amino-9-(2-deoxy-2-fluoro-5-O-phosphono-beta-D-arabinofuranosyl)-7-methyl-6-oxo-6,9-dihydro-1h-purin-7-ium
Glycosylation
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Modification
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Structure summary

Code : 6UI2   PDBj   RCSB PDB   PDBe
Header : DNA BINDING PROTEIN/DNA
Title : Structure of human DNA polymerase eta complexed with N7MG in the template base paired with incoming non-hydrolyzable CTP
Release Data : 2020-01-15
Compound :
mol_id molecule chains synonym
1 DNA polymerase eta A RAD30 homolog A,Xeroderma pigmentosum variant type protein
ec: 2.7.7.7
mol_id molecule chains
2 DNA (5'-D(*CP*AP*TP*(FMG)P*AP*TP*GP*AP*CP*GP*CP*T)-3') T
mol_id molecule chains
3 DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3') P
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: POLH, RAD30, RAD30A, XPV
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
synthetic: yes
mol_id organism_scientific organism_common
3 Homo sapiens  (taxid:9606) Human
synthetic: yes
Authors : Koag, M.C., Lee, S.
Keywords : DNA BINDING PROTEIN, DNA BINDING PROTEIN-DNA complex
Exp. method : X-RAY DIFFRACTION ( 2.35 Å )
Citation :

Bypass of the Major Alkylative DNA Lesion by Human DNA Polymerase eta.

Koag, M.C.,Jung, H.,Kou, Y.  et al.
(2019)  Molecules  24

PubMed: 31683505
DOI: 10.3390/molecules24213928

Reaction

Chain : A
UniProt : Q9Y253 (POLH_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate 2.7.7.7 PubMed:27284197, PubMed:38212351
-
Cofactor: Evidence: Note:
Mn(2+) ECO:0000269 | PubMed:27284197
ECO:0000269 | PubMed:27284197
Binds 2 Mg(2+) (PubMed:27284197). Prefers Mg(2+), but can also use Mn(2+) (PubMed:27284197). In vitro, can also utilize other divalent cations such as Ca(2+) (PubMed:27284197).