Brand  (β version)

PDB ID: 6SO2

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
JGG N-[(4-cyanophenyl)methyl]morpholine-4-carboxamide PoSSuM
MG Magnesium ion PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 6SO2   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Fragment N13460a in complex with MAP kinase p38-alpha
Release Data : 2019-10-02
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase 14 A MAPK 14,CRK1,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha
ec: 2.7.11.24
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) House mouse Escherichia coli  (taxid:562)
gene: Mapk14, Crk1, Csbp1, Csbp2
Authors : Nichols, C.E., De Nicola, G.F.
Keywords : FBDD, Fragment Based Drug Design, P38, MAPK14, Kinase, Transferase., TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.60 Å )
Citation :

Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes.

Nichols, C.,Ng, J.,Keshu, A.  et al.
(2020)  J.Med.Chem.  63 : 7559 - 7568

PubMed: 32543856
DOI: 10.1021/acs.jmedchem.0c00403

Reaction

Chain : A
UniProt : P47811 (MK14_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.24 PubMed:18669639, PubMed:22375048
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.24 PubMed:18669639, PubMed:22375048
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