Het-PDB Navi2 (PDB: 6S9K)

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Ligands
Code	Name		Style	Show	Link
CFH	1,1,1,3,3,3-hexafluoropropan-2-ol				PoSSuM

Non-standard Residues
Code	Name	Show
SEP	Phosphoserine

Glycosylation
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Download interaction data: 6S9K

Code :

6S9K PDBj RCSB PDB PDBe

Header :

SIGNALING PROTEIN

Title :

Structure of 14-3-3 gamma in complex with caspase-2 peptide containing 14-3-3 binding motif Ser139 and NLS

Release Data :

2020-01-22

Compound :

mol_id	molecule	chains	synonym
1	14-3-3 protein gamma	A	Protein kinase C inhibitor protein 1,KCIP-1
	mutation: none

mol_id	molecule	chains	synonym
2	Caspase-2	B	CASP-2,Neural precursor cell expressed developmentally down-regulated protein 2,NEDD-2,Protease ICH-1
	ec: 3.4.22.55 other_details: Caspase-2

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: YWHAG

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes

Authors :

Alblova, M., Obsil, T., Obsilova, V.

Keywords :

14-3-3, caspase-2, phosphorylation, NLS, SIGNALING PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 1.600 Å )

Citation :

14-3-3 protein binding blocks the dimerization interface of caspase-2.

Kalabova, D.,Filandr, F.,Alblova, M. et al.
(2020) Febs J. 287 : 3494 - 3510

Chain :

UniProt :

P42575 (CASP2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Strict requirement for an Asp residue at P1, with 316-Asp being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-\|-.	3.4.22.55	-
	-	-

PDB ID: 6S9K