Brand  (β version)

PDB ID: 6S7T

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Ligands
Code Name Style Show Link
0K3 (2z,6z,10z,14z,18z,22z,26z)-3,7,11,15,19,23,27,31-octamethyldotriaconta-2,6,10,14,18,22,26,30-octaen-1-yl dihydrogen phosphate PoSSuM
EGY (4r,7r)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(undecanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphadocosan-1-aminium PoSSuM
KZB (2~{S},3~{R},4~{R},5~{S},6~{S})-2-(hydroxymethyl)-6-[(1~{S},2~{R},3~{R},4~{R},5'~{S},6~{S},7~{R},8~{S},9~{R},12~{R},13~{R},15~{S},16~{S},18~{R})-5',7,9,13-tetramethyl-3,15-bis(oxidanyl)spiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2'-oxane]-16-yl]oxy-oxane-3,4,5-triol PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
BMA Beta-D-mannopyranose
MAN Alpha-D-mannopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 6S7T   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Cryo-EM structure of human oligosaccharyltransferase complex OST-B
Release Data : 2019-12-18
Compound :
mol_id molecule chains synonym
1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B A STT3-B,Source of immunodominant MHC-associated peptides homolog
ec: 2.4.99.18
mol_id molecule chains
2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 B
mol_id molecule chains synonym
3 Transmembrane protein 258 C Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258,Oligosaccharyl transferase subunit TMEM258
mol_id molecule chains synonym
4 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 D Oligosaccharyl transferase subunit DAD1,Defender against cell death 1,DAD-1
mol_id molecule chains synonym
5 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 E Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit,Ribophorin I,RPN-I,Ribophorin-1
mol_id molecule chains synonym
6 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 F Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit,RIBIIR,Ribophorin II,RPN-II,Ribophorin-2
mol_id molecule chains synonym
7 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit G Oligosaccharyl transferase 48 kDa subunit
mol_id molecule chains synonym
8 Magnesium transporter protein 1 H MagT1,Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1,Oligosaccharyl transferase subunit MAGT1,Implantation-associated protein,IAP
mol_id molecule chains
9 Malectin I
mol_id molecule chains
10 PEPTIDE K
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
3 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
4 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
5 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
6 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
7 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common expression_system
8 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
gene: MAGT1, IAG2, PSEC0084, UNQ628/PRO1244
mol_id organism_scientific organism_common
9 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
10 Homo sapiens  (taxid:9606) Human
Authors : Ramirez, A.S., Kowal, J., Locher, K.P.
Keywords : N-glycosylation, Oligosaccharyltransferase, OSTB, TRANSFERASE
Exp. method : ELECTRON MICROSCOPY ( 3.5 Å )
Citation :

Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B.

Ramirez, A.S.,Kowal, J.,Locher, K.P.
(2019)  Science  366 : 1372 - 1375

PubMed: 31831667
DOI: 10.1126/science.aaz3505

Reaction

Chain : A
UniProt : Q8TCJ2 (STT3B_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = a dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N- acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L- asparaginy-[protein] 2.4.99.18 UniProtKB:P39007
-
Chain : B
UniProt : P0C6T2 (OST4_HUMAN)
Reaction : -
Chain : C
UniProt : P61165 (TM258_HUMAN)
Reaction : -
Chain : D
UniProt : P61803 (DAD1_HUMAN)
Reaction : -
Chain : E
UniProt : P04843 (RPN1_HUMAN)
Reaction : -
Chain : F
UniProt : P04844 (RPN2_HUMAN)
Reaction : -
Chain : G
UniProt : A0A024RAD5
Reaction : -
Chain : H
UniProt : Q9H0U3 (MAGT1_HUMAN)
Reaction : -
Chain : I
UniProt : Q14165 (MLEC_HUMAN)
Reaction : -