Brand  (β version)

PDB ID: 6S6D

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Code Name Style Show Link
GTP Guanosine-5'-triphosphate PoSSuM
MG Magnesium ion PoSSuM
GDP Guanosine-5'-diphosphate PoSSuM

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Structure summary

Code : 6S6D   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : Crystal structure of RagA-Q66L-GTP/RagC-S75N-GDP GTPase heterodimer complex
Release Data : 2019-10-16
Compound :
mol_id molecule chains synonym
1 Ras-related GTP-binding protein A A,B RagA,Adenovirus E3 14.7 kDa-interacting protein 1,FIP-1
mutation: Q66L
mol_id molecule chains synonym
2 Ras-related GTP-binding protein C C,D RagC,GTPase-interacting protein 2,TIB929
mutation: S75N
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: RRAGA
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: RRAGC
Authors : Anandapadamanaban, M., Masson, G.R., Perisic, O., Kaufman, J., Williams, R.L.
Keywords : small GTPases, mTORC1 activator, roadblock domain, GTPase domain, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.5000 Å )
Citation :

Architecture of human Rag GTPase heterodimers and their complex with mTORC1.

Anandapadamanaban, M.,Masson, G.R.,Perisic, O.  et al.
(2019)  Science  366 : 203 - 210

PubMed: 31601764
DOI: 10.1126/science.aax3939

Reaction

Chain : A, B
UniProt : Q7L523 (RRAGA_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + phosphate + H(+) - PubMed:32868926, PubMed:24095279
left-to-right PubMed:24095279
Chain : C, D
UniProt : Q9HB90 (RRAGC_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + phosphate + H(+) - PubMed:11073942, PubMed:32868926, PubMed:24095279
left-to-right PubMed:11073942, PubMed:24095279