Brand  (β version)

PDB ID: 6RCT

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Ligands
Code Name Style Show Link
JWN 4-[2-methyl-1-(4-methylpiperazin-1-yl)-1-oxidanylidene-propan-2-yl]-~{N}-(6-pyridin-4-ylimidazo[1,2-a]pyridin-2-yl)benzamide PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6RCT   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of CLK3 in complex with T3-CLK
Release Data : 2019-05-01
Compound :
mol_id molecule chains synonym
1 Dual specificity protein kinase CLK3 A,B CDC-like kinase 3
ec: 2.7.12.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CLK3
expression_system_cell_line: BL21(DE3)-R3-pRARE2
expression_system_vector_type: plasmid
expression_system_plasmid: pNIC28-Bsa4
Authors : Chaikuad, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Keywords : CLK3, splicing kinase, probe, kinase inhibitor, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.3200 Å )
Citation :

Crystal structure of CLK3 in complex with TP003

Chaikuad, A.,Arrowsmith, C.H.,Edwards, A.M.  et al.
To Be Published 

Reaction

Chain : A, B
UniProt : P49761 (CLK3_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.12.1 -
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.12.1 -
-
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.12.1 -
-