PDB ID: 6RAV
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Structure summary
Code : | 6RAV PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE | ||||||||||||
Title : | Complement factor B protease domain in complex with the reversible inhibitor 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid | ||||||||||||
Release Data : | 2019-04-17 | ||||||||||||
Compound : |
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Source : |
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Authors : | Adams, C.M., Sellner, H., Ehara, T., Mac Sweeney, A., Crowley, M., Anderson, K., Karki, R., Mainolfi, N., Valeur, E., Sirockin, F., Gerhartz, B., Erbel, P., Hughes, N., Smith, T.M., Cumin, F., Argikar, U., Mogi, M., Sedrani, R., Wiesmann, C., Jaffee, B., Maibaum, J., Flohr, S., Harrison, R., Eder, J. | ||||||||||||
Keywords : | Complement, immune, inhibitor, c3 convertase, HYDROLASE | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.700 Å ) | ||||||||||||
Citation : |
Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
Schubart, A.,Anderson, K.,Mainolfi, N.
et al.
PubMed: 30926668 Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
Schubart, A.,Anderson, K.,Mainolfi, N.
et al.
PubMed: 30926668 |
Reaction
Chain : | AAA, BBB | ||||||||
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UniProt : | P00751 (CFAB_HUMAN) | ||||||||
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