Brand  (β version)

PDB ID: 6RAA

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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
JWN 4-[2-methyl-1-(4-methylpiperazin-1-yl)-1-oxidanylidene-propan-2-yl]-~{N}-(6-pyridin-4-ylimidazo[1,2-a]pyridin-2-yl)benzamide PoSSuM
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Structure summary

Code : 6RAA   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : CLK1 Kinase domain with bound imidazopyridin inhibitor TP003
Release Data : 2019-04-24
Compound :
mol_id molecule chains synonym
1 Dual specificity protein kinase CLK1 A CDC-like kinase 1
ec: 2.7.12.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CLK1, CLK
Authors : Schroeder, M., Arrowsmith, C., Knapp, S., Bountra, C., Edwards, A., Structural Genomics Consortium (SGC)
Keywords : Inhibitor, Kinase, Transferase, Structural Genomics, Structural Genomics Consortium, SGC
Exp. method : X-RAY DIFFRACTION ( 2.1000 Å )
Citation :

CLK1 Kinase domain with bound imidazopyridin inhibitor TP003

Schroeder, M.,Arrowsmith, C.,Knapp, S.  et al.
To Be Published 

Reaction

Chain : A
UniProt : P49759 (CLK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.12.1 PubMed:10480872
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.12.1 UniProtKB:P22518
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ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.12.1 UniProtKB:P22518
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