Brand  (β version)

PDB ID: 6R8P

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Ligands
Code Name Style Show Link
DMS Dimethyl sulfoxide PoSSuM
GOL Glycerol PoSSuM
JVB 2-(2-methylphenoxy)-~{N}-pyridin-3-yl-ethanamide PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 6R8P   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Notum fragment 723
Release Data : 2019-05-08
Compound :
mol_id molecule chains synonym
1 Palmitoleoyl-protein carboxylesterase NOTUM A hNOTUM
ec: 3.1.1.98
mutation: C330S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
gene: NOTUM, OK/SW-CL.30
expression_system_common: Human
expression_system_cell_line: HEK293S GNTI-
Authors : Zhao, Y., Jones, E.Y.
Keywords : Notum inhibitor, Hydrolase
Exp. method : X-RAY DIFFRACTION ( 1.4500 Å )
Citation :

Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.

Atkinson, B.N.,Steadman, D.,Zhao, Y.  et al.
(2019)  Medchemcomm  10 : 1361 - 1369

PubMed: 31534655
DOI: 10.1039/c9md00096h

Reaction

Chain : A
UniProt : Q6P988 (NOTUM_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O = (9Z)- hexadecenoate + [Wnt protein]-L-serine + H(+) 3.1.1.98 PubMed:25731175
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