Brand  (β version)

PDB ID: 6R2W

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Ligands
Code Name Style Show Link
0Z7 N-acetyl-D-phenylalanyl-N-[(2s,3s)-6-carbamimidamido-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide PoSSuM
CA Calcium ion PoSSuM
TMA Tetramethylammonium ion PoSSuM
Non-standard Residues
Code Name Show
CGU Gamma-carboxy-glutamic acid
Glycosylation
Code Name Emphasize
BGC Beta-D-glucopyranose
FUC Alpha-L-fucopyranose
XYS Alpha-D-xylopyranose
Modification
Code Name Show

Structure summary

Code : 6R2W   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of the super-active FVIIa variant VYT in complex with tissue factor
Release Data : 2019-12-11
Compound :
mol_id molecule chains synonym
1 Coagulation factor VII L Proconvertin,Serum prothrombin conversion accelerator,SPCA
ec: 3.4.21.21
mol_id molecule chains synonym
2 Coagulation factor VII H Proconvertin,Serum prothrombin conversion accelerator,SPCA
ec: 3.4.21.21
mutation: L350V,371-375del,K376E,V377A,G378S,D379Y,S380P,P381G,N382K
mol_id molecule chains synonym
3 Tissue factor T TF,Coagulation factor III,Thromboplastin
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Cricetulus griseus  (taxid:10029)
organ: KIDNEY
tissue: BLOOD
gene: F7
expression_system_cell_line: CHOEBNALT85
expression_system_vector_type: PLASMID
expression_system_plasmid: PQMCF-5
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Cricetulus griseus  (taxid:10029)
organ: KIDNEY
tissue: BLOOD
gene: F7
expression_system_cell_line: CHOEBNALT85
expression_system_vector_type: PLASMID
expression_system_plasmid: PQMCF-5
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
tissue: Blood
gene: F3
expression_system_strain: ORIGAMI 2
expression_system_vector_type: PLASMID
expression_system_plasmid: PET3A
Authors : Sorensen, A.B., Svensson, L.A., Gandhi, P.S.
Keywords : TRYPSIN-FOLD, PROTEIN-PROTEIN COMPLEX, HYDROLASE, COAGULATION FACTOR
Exp. method : X-RAY DIFFRACTION ( 1.2500 Å )
Citation :

Beating tissue factor at its own game: Design and properties of a soluble tissue factor-independent coagulation factor VIIa.

Sorensen, A.B.,Tuneew, I.,Svensson, L.A.  et al.
(2020)  J.Biol.Chem.  295 : 517 - 528

PubMed: 31801825
DOI: 10.1074/jbc.RA119.009183

Reaction

Chain : H
UniProt : P08709 (FA7_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa. 3.4.21.21 -
-
Chain : T
UniProt : P13726 (TF_HUMAN)
Reaction : -