Brand  (β version)

PDB ID: 6QYA

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Ligands
Code Name Style Show Link
UMP 2'-deoxyuridine 5'-monophosphate PoSSuM
EDO 1,2-ethanediol PoSSuM
FFO N-[4-({[(6s)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
Code Name Show
CSX S-oxy cysteine
CME S,S-(2-hydroxyethyl)thiocysteine
Glycosylation
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Modification
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Structure summary

Code : 6QYA   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of Enteroccocus faecalis thymidylate synthase (EfTS) in complex with dUMP
Release Data : 2019-04-10
Compound :
mol_id molecule chains synonym
1 Thymidylate synthase A,C TSase
ec: 2.1.1.45
mol_id molecule chains synonym
2 Thymidylate synthase B,D TSase
ec: 2.1.1.45
Source :
mol_id organism_scientific expression_system
1 Enterococcus faecalis  (taxid:1351) Escherichia coli  (taxid:562)
gene: thyA, EF_1576
mol_id organism_scientific expression_system
2 Enterococcus faecalis  (taxid:1351) Escherichia coli  (taxid:562)
gene: thyA, EF_1576
Authors : Pozzi, C., Mangani, M.
Keywords : Enteroccocus faecalis thymidylate synthase, EfTS, folate pathway, substrate, dUMP, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.76 Å )
Citation :

Structural Comparison ofEnterococcus faecalisand Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities.

Pozzi, C.,Ferrari, S.,Luciani, R.  et al.
(2019)  Molecules  24

PubMed: 30935102
DOI: 10.3390/molecules24071257

Reaction

Chain : B, D
UniProt : Q834R3 (TYSY_ENTFA)
Reaction: EC: Evidence:
Physiological Direction:
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8- dihydrofolate + dTMP 2.1.1.45 HAMAP-Rule:MF_00008
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