Brand  (β version)

PDB ID: 6QXD

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Ligands
Code Name Style Show Link
CU Copper (II) ion PoSSuM
JKB (2,4-dinitrophenyl)-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]methanone PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6QXD   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal Structure of tyrosinase from Bacillus megaterium with JKB inhibitor in the active site.
Release Data : 2019-06-19
Compound :
mol_id molecule chains
1 Tyrosinase A,B
Source :
mol_id organism_scientific expression_system
1 Bacillus megaterium  (taxid:1404) Escherichia coli BL21  (taxid:511693)
Authors : Deri Zenaty, B., Gitto, R., Pazy, Y., Fishman, A.
Keywords : Tyrosinase, Inhibitor, Ligand, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.317 Å )
Citation :

Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile.

Ielo, L.,Deri, B.,Germano, M.P.  et al.
(2019)  Eur.J.Med.Chem.  178 : 380 - 389

PubMed: 31202126
DOI: 10.1016/j.ejmech.2019.06.019

Reaction

Chain : A, B
UniProt : B2ZB02 (B2ZB02_PRIMG)
Reaction : -