Brand  (β version)

PDB ID: 6QX3

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Ligands
Code Name Style Show Link
Non-standard Residues
Code Name Show
P 2'-deoxy-n1,n2-propano guanosine monophosphate
Glycosylation
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Modification
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Structure summary

Code : 6QX3   PDBj   RCSB PDB   PDBe
Header : RNA BINDING PROTEIN
Title : Influenza A virus (A/NT/60/1968) polymerase Hetermotrimer in complex with 3'5' cRNA promoter and Nb8205
Release Data : 2019-09-04
Compound :
mol_id molecule chains
1 RNA (5'-R(P*AP*GP*CP*AP*AP*AP*AP*GP*CP*A)-3') D
mol_id molecule chains
2 RNA (5'-R(P*UP*UP*CP*U)-3') G
mol_id molecule chains
3 Nb8205 O
mol_id molecule chains synonym
4 RNA-directed RNA polymerase catalytic subunit B Polymerase basic protein 1,PB1,RNA-directed RNA polymerase subunit P1
ec: 2.7.7.48
mol_id molecule chains synonym
5 Polymerase acidic protein A RNA-directed RNA polymerase subunit P2
ec: 3.1.-.-
mol_id molecule chains synonym
6 Polymerase basic protein 2 C RNA-directed RNA polymerase subunit P3
Source :
mol_id organism_scientific
1 Influenza A virus (A/nt/60/1968(H3N2))  (taxid:384505)
synthetic: yes
mol_id organism_scientific
2 Influenza A virus (A/nt/60/1968(H3N2))  (taxid:384505)
synthetic: yes
mol_id organism_scientific organism_common expression_system
3 Lama glama  (taxid:9844) Llama Escherichia coli  (taxid:562)
mol_id organism_scientific expression_system
4 Influenza A virus (strain A/Hong Kong/1/1968 H3N2)  (taxid:506350) Spodoptera frugiperda  (taxid:7108)
strain: A/Hong Kong/1/1968 H3N2
gene: PB1
mol_id organism_scientific organism_common expression_system
5 Influenza A virus (strain A/Northern Territory/60/1968 H3N2)  (taxid:384505) Influenza A virus (strain NT60) Spodoptera frugiperda  (taxid:7108)
strain: A/Northern Territory/60/1968 H3N2
gene: PA
mol_id organism_scientific organism_common expression_system
6 Influenza A virus (strain A/Northern Territory/60/1968 H3N2)  (taxid:384505) Influenza A virus (strain NT60) Spodoptera frugiperda  (taxid:7108)
strain: A/Northern Territory/60/1968 H3N2
gene: PB2
Authors : Carrique, L., Keown, J.R., Fan, H., Fodor, E., Grimes, J.M.
Keywords : Influenza A, RNA polymerase, Influenza polymerase, Influenza dimer, RDRP, RNA BINDING PROTEIN
Exp. method : ELECTRON MICROSCOPY ( 3.79 Å )
Citation :

Structures of influenza A virus RNA polymerase offer insight into viral genome replication.

Fan, H.,Walker, A.P.,Carrique, L.  et al.
(2019)  Nature  573 : 287 - 290

PubMed: 31485076
DOI: 10.1038/s41586-019-1530-7

Reaction

Chain : B
UniProt : Q910D6 (RDRP_I68A4)
Reaction: EC: Evidence:
Physiological Direction:
RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate 2.7.7.48 HAMAP-Rule:MF_04065
-
Chain : A
UniProt : P03434 (PA_I68A6)
Reaction : -
Cofactor: Evidence: Note:
Mn(2+) ECO:0000255 | HAMAP-Rule:MF_04063
Binds 2 manganese ions per subunit.
Chain : C
UniProt : P03429 (PB2_I68A6)
Reaction : -