PDB ID: 6QSX
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Structure summary
Code : | 6QSX PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE | ||||||||||||
Title : | Complement factor B protease domain in complex with the reversible inhibitor ((2S,4S)-1-((5,7-dimethyl-1H-indol-4-yl)methyl)-4-methoxypiperidin-2-yl)methanol. | ||||||||||||
Release Data : | 2019-03-27 | ||||||||||||
Compound : |
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Source : |
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Authors : | Adams, C.M., Sellner, H., Ehara, T., Mac Sweeney, A., Crowley, M., Anderson, K., Karki, R., Mainolfi, N., Valeur, E., Sirockin, F., Gerhartz, B., Erbel, P., Hughes, N., Smith, T.M., Cumin, F., Argikar, U., Mogi, M., Sedrani, R., Wiesmann, C., Jaffee, B., Maibaum, J., Flohr, S., Harrison, R., Eder, J. | ||||||||||||
Keywords : | Complement, immune, inhibitor, c3 convertase, HYDROLASE | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.770 Å ) | ||||||||||||
Citation : |
Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
Schubart, A.,Anderson, K.,Mainolfi, N.
et al.
PubMed: 30926668 |
Reaction
Chain : | AAA, BBB | ||||||||
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UniProt : | P00751 (CFAB_HUMAN) | ||||||||
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