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Ligands
Code Name Style Show Link
J6T 2-[2-[[3-[3-[(1~{S})-1-azanyl-2-oxidanyl-ethyl]phenyl]phenyl]methoxy]phenyl]ethanoic acid
Non-standard Residues
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Glycosylation
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Code : 6QMR   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Complement factor D in complex with the inhibitor (S)-2-(2-((3'-(1-amino-2-hydroxyethyl)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)acetic acid
Release Data : 2019-04-24
Compound :
mol_id molecule chains synonym
1 Complement factor D A,B,C,D,E,F Adipsin,C3 convertase activator,Properdin factor D
ec: 3.4.21.46
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CFD, DF, PFD
Authors : Karki, R., Powers, J., Mainolfi, N., Anderson, K., Belanger, D., Liu, D., Jendza, K., Gelin, C.F., Solovay, C., Mac Sweeeny, A., Delgado, O., Crowley, M., Liao, S.-M., Argikar, U.A., Flohr, S., La Bonte, L.R., Lorthiois, E.L., Vulpetti, A., Cumin, F., Brown, A., Adams, C., Jaffee, B., Mogi, M.
Keywords : Complement factor D, inhibitor, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.0000 Å )
Citation :

Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway.

Karki, R.G.,Powers, J.,Mainolfi, N.  et al.
(2019)  J.Med.Chem.  62 : 4656 - 4668

PubMed: 30995036
DOI: 10.1021/acs.jmedchem.9b00271

Chain : A, B, C, D, E, F
UniProt : P00746 (CFAD_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor. 3.4.21.46 -
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