Brand  (β version)

PDB ID: 6QM7

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Ligands
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J6E ~{N}-[4-fluoranyl-3-(3-morpholin-4-ylimidazo[1,2-a]pyrimidin-7-yl)phenyl]pyrrolidine-1-carboxamide PoSSuM
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Structure summary

Code : 6QM7   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Leishmania tarentolae proteasome 20S subunit complexed with GSK3494245
Release Data : 2019-04-17
Compound :
mol_id molecule chains
1 Proteasome alpha1 chain A,O
mol_id molecule chains
2 Proteasome alpha2 chain B,P
mol_id molecule chains
3 Proteasome alpha3 chain C,Q
mol_id molecule chains
4 Proteasome alpha4 chain D,R
mol_id molecule chains
5 Proteasome alpha5 chain E,S
mol_id molecule chains
6 Proteasome alpha6 chain F,T
mol_id molecule chains
7 Proteasome alpha7 chain G,U
mol_id molecule chains
8 Proteasome beta1 chain H,V
mol_id molecule chains
9 Proteasome beta2 chain I,W
mol_id molecule chains
10 Proteasome beta3 chain J,X
mol_id molecule chains
11 Proteasome beta4 chain K,Y
mol_id molecule chains
12 Proteasome beta5 chain L,Z
mol_id molecule chains
13 Proteasome beta6 chain M,a
mol_id molecule chains
14 Proteasome beta7 chain N,b
Source :
mol_id organism_scientific
1 Leishmania tarentolae  (taxid:5689)
mol_id organism_scientific
2 Leishmania tarentolae  (taxid:5689)
mol_id organism_scientific
3 Leishmania tarentolae  (taxid:5689)
mol_id organism_scientific
4 Leishmania tarentolae  (taxid:5689)
mol_id organism_scientific
5 Leishmania tarentolae  (taxid:5689)
mol_id organism_scientific
6 Leishmania tarentolae  (taxid:5689)
mol_id organism_scientific
7 Leishmania tarentolae  (taxid:5689)
mol_id organism_scientific
8 Leishmania tarentolae  (taxid:5689)
mol_id organism_scientific
9 Leishmania tarentolae  (taxid:5689)
mol_id organism_scientific
10 Leishmania tarentolae  (taxid:5689)
mol_id organism_scientific
11 Leishmania tarentolae  (taxid:5689)
mol_id organism_scientific
12 Leishmania tarentolae  (taxid:5689)
mol_id organism_scientific
13 Leishmania tarentolae  (taxid:5689)
mol_id organism_scientific
14 Leishmania tarentolae  (taxid:5689)
Authors : Rowland, P., Goswami, P.
Keywords : Proteasome 20S subunit, hydrolase
Exp. method : ELECTRON MICROSCOPY ( 2.8 Å )
Citation :

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.

Wyllie, S.,Brand, S.,Thomas, M.  et al.
(2019)  Proc.Natl.Acad.Sci.USA  116 : 9318 - 9323

PubMed: 30962368
DOI: 10.1073/pnas.1820175116