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Ligands
Code Name Style Show Link
CL Chloride ion
CTC 7-chlorotetracycline
MG Magnesium ion
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Glycosylation
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Code : 6QJW   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : TetR(D) T103A mutant in complex with 7-chlortetracycline and magnesium
Release Data : 2019-08-21
Compound :
mol_id molecule chains
1 Tetracycline repressor protein class D A
mutation: A2S, T103A
other_details: stop codon at 209, C-terminus removed for better crystallization
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli K-12  (taxid:83333)
gene: tetR
expression_system_plasmid: pWH1950
Authors : Hinrichs, W., Palm, G.J., Berndt, L., Girbardt, B.
Keywords : TRANSCRIPTION REGULATION, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.

Palm, G.J.,Buchholz, I.,Werten, S.  et al.
(2020)  Biochim Biophys Acta Proteins Proteom  1868 : 140404 - 140404

PubMed: 32114262
DOI: 10.1016/j.bbapap.2020.140404

Modular organisation of inducer recognition and allostery in the tetracycline repressor.

Werten, S.,Schneider, J.,Palm, G.J.  et al.
(2016)  FEBS J.  283 : 2102 - 2114

PubMed: 27028290
DOI: 10.1111/febs.13723

Chain : A
UniProt : P0ACT4 (TETR4_ECOLX)
Reaction : -