Brand  (β version)

PDB ID: 6QJE

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Ligands
Code Name Style Show Link
HFK 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one PoSSuM
J4Q 4-[(2-methylsulfonylimidazol-1-yl)methyl]-1,3-thiazole PoSSuM
GAL Beta-D-galactopyranose PoSSuM
Non-standard Residues
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Structure summary

Code : 6QJE   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structure of human galactokinase 1 bound with 4-{[2-(Methylsulfonyl)-1H-imidazol-1-yl]methyl}-1,3-thiazole
Release Data : 2019-02-27
Compound :
mol_id molecule chains synonym
1 Galactokinase A,B,C,D Galactose kinase
ec: 2.7.1.6
mutation: K252A, E253A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: GALK1, GALK
Authors : Mackinnon, S.R., Bezerra, G.A., Zhang, M., Foster, W., Krojer, T., Brandao-Neto, J., Douangamath, A., Arrowsmith, C., Edwards, A., Bountra, C., Brennan, P., Lai, K., Yue, W.W.
Keywords : GALK1, fragment, fragment-bound, galactokinase 1, sugar kinase, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.4000 Å )
Citation :

Structure of human galactokinase 1 bound with 4-{[2-(Methylsulfonyl)-1H-imidazol-1-yl]methyl}-1,3-thiazole

Mackinnon, S.R.,Bezerra, G.A.,Zhang, M.  et al.
To Be Published 

Reaction

Chain : A, B, C, D
UniProt : P51570 (GALK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+) 2.7.1.6 PubMed:12694189, PubMed:7542884
left-to-right PubMed:7542884