Het-PDB Navi2 (PDB: 6QH9)

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Ligands
Code	Name	Link
UNX	Unknown atom or ion	PoSSuM
J2N	(3~{S})-~{N}-(4-carbamimidoylphenyl)-2-oxidanylidene-piperidine-3-carboxamide	PoSSuM
J3B	(3~{R})-~{N}-(4-carbamimidoylphenyl)-2-oxidanylidene-piperidine-3-carboxamide	PoSSuM

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Download interaction data: 6QH9

Code :

6QH9 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal Structure of Human Kallikrein 6 in complex with GSK3239861A

Release Data :

2019-02-06

Compound :

mol_id	molecule	chains	synonym
1	Kallikrein-6	A,B	Neurosin,Protease M,SP59,Serine protease 18,Serine protease 9,Zyme
	ec: 3.4.21.- mutation: R74G/R76Q/N132Q

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Baculovirus expression vector pFastBac1-HM (taxid:274590)
	gene: KLK6, PRSS18, PRSS9

Authors :

Thorpe, J.H.

Keywords :

Protease, Inhibitor, Complex, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.27 Å )

Citation :

Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome.

White, G.V.,Edgar, E.V.,Holmes, D.S. et al.
(2019) Bioorg. Med. Chem. Lett. 29 : 821 - 825

PDB ID: 6QH9