Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
J1H [(3~{R})-3-[[4-[[4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]phenyl]carbonylsulfamoyl]-2-nitro-phenyl]amino]-4-phenylsulfanyl-butyl]-(2-hydroxy-2-oxoethyl)-dimethyl-azanium
Code : 6QGG
Header : APOPTOSIS
Title : Structure of human Bcl-2 in complex with analogue of ABT-737
Release Data : 2019-06-12
Compound :
mol_id molecule chains synonym
1 Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2,Bcl-2-like protein 1 A Bcl2-L-1,Apoptosis regulator Bcl-X,Bcl2-L-1,Apoptosis regulator Bcl-X
mutation: H20S, L95Q, R106L, F124G, R127Y, G128A, R129S, P168V, L175A, T178A, E179T, R183D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21  (taxid:511693)
gene: BCL2L1, BCL2L, BCLX
expression_system_variant: pLysS
Authors : Dokurno, P., Murray, J., Davidson, J., Chen, I., Davis, B., Graham, C.J., Harris, R., Jordan, A.M., Matassova, N., Pedder, C., Ray, S., Roughley, S., Smith, J., Walmsley, C., Wang, Y., Whitehead, N., Williamson, D.S., Casara, P., Le Diguarher, T., Hickman, J., Stark, J., Kotschy, A., Geneste, O., Hubbard, R.E.
Keywords : APOPTOSIS, BCL2, ABT-737
Exp. method : X-RAY DIFFRACTION ( 1.5000 Å )
Citation :

Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1

Murray, J.,Davidson, J.,Chen, I.  et al.
(2019)  Acs Omega 

DOI: 10.1021/acsomega.9b00611

Chain : A
UniProt : P10415 (BCL2_HUMAN)
Reaction : -
Chain : A
UniProt : Q07817 (B2CL1_HUMAN)
Reaction : -