Brand  (β version)

PDB ID: 6QFT

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Ligands
Code Name Style Show Link
J0B 1-[(3~{R})-3-(4-azanyl-3-iodanyl-pyrazolo[3,4-D]pyrimidin-1-yl)piperidin-1-yl]propan-1-one PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6QFT   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidin 1b
Release Data : 2019-05-22
Compound :
mol_id molecule chains synonym
1 Dual specificity mitogen-activated protein kinase kinase 7 A MAPKK 7,JNK-activating kinase 2,MAPK/ERK kinase 7,MEK 7,Stress-activated protein kinase kinase 4,SAPKK4,c-Jun N-terminal kinase kinase 2,JNKK 2
ec: 2.7.12.2
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: MAP2K7, JNKK2, MEK7, MKK7, PRKMK7, SKK4
Authors : Wolle, P., Mueller, M.P., Rauh, D.
Keywords : Protein Kinase, Kinase, MKK7, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.7 Å )
Citation :

Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7).

Wolle, P.,Engel, J.,Smith, S.  et al.
(2019)  J.Med.Chem.  62 : 5541 - 5546

PubMed: 31083997
DOI: 10.1021/acs.jmedchem.9b00472

Reaction

Chain : A
UniProt : O14733 (MP2K7_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.12.2 -
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.12.2 -
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ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.12.2 -
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