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Ligands
Code Name Style Show Link
FE7 N-{(3z)-2-oxo-3-[phenyl({4-[(piperidin-1-yl)methyl]phenyl}amino)methylidene]-2,3-dihydro-1h-indol-5-yl}ethanesulfonamide
Non-standard Residues
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Glycosylation
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Code : 6QAT   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of ULK2 in complexed with hesperadin
Release Data : 2019-02-27
Compound :
mol_id molecule chains synonym
1 Serine/threonine-protein kinase ULK2 A,B,C,D Unc-51-like kinase 2
ec: 2.7.11.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: ULK2, KIAA0623
expression_system_variant: R3-pARE2
expression_system_vector_type: plasmid
expression_system_plasmid: pNIC28-Bsa4
Authors : Chaikuad, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Keywords : ULK2, autophagy, kinase, inhibitor complex, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.77 Å )
Citation :

Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2).

Chaikuad, A.,Koschade, S.E.,Stolz, A.  et al.
(2019)  Biochem.J.  476 : 875 - 887

PubMed: 30782972
DOI: 10.1042/BCJ20190038

Chain : A, B, C, D
UniProt : Q8IYT8 (ULK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 -
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 -
-