Het-PDB Navi2 (PDB: 6PV9)

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Ligands
Code	Name		Style	Show	Link

Glycosylation
Code	Name	Emphasize

Modification
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ACE	Acetyl group
NH2	Amino group

Download interaction data: 6PV9

Code :

6PV9 PDBj RCSB PDB PDBe

Header :

IMMUNE SYSTEM

Title :

Human PD-L1 bound to a macrocyclic peptide which blocks the PD-1/PD-L1 interaction

Release Data :

2020-01-01

Compound :

mol_id	molecule	chains	synonym
1	Programmed cell death 1 ligand 1	A	PD-L1, Programmed death ligand 1, B7 homolog 1, B7-H1
	fragment: extracellular domain (UNP residues 19-239)

mol_id	molecule	chains
2	macrocyclic peptide	B

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1

mol_id	organism_scientific
2	Synthetic construct (taxid:32630)
	synthetic: yes

Authors :

Appleby, T.C., Lad, L., Gross, M.L.

Keywords :

PD-L1 PD-1 Cancer Immunotherapy Checkpoint Inhibitor, IMMUNE SYSTEM

Exp. method :

X-RAY DIFFRACTION ( 2.0 Å )

Citation :

Protein Footprinting and X-ray Crystallography Reveal the Interaction of PD-L1 and a Macrocyclic Peptide.

Niu, B.,Appleby, T.C.,Wang, R. et al.
(2020) Biochemistry 59 : 541 - 551

PDB ID: 6PV9