Brand  (β version)

PDB ID: 6PS3

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Ligands
Code Name Style Show Link
CLR Cholesterol PoSSuM
CVD (2s)-1-(8h-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol PoSSuM
OLA Oleic acid PoSSuM
OLC (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6PS3   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : XFEL beta2 AR structure by ligand exchange from Timolol to Carvedilol.
Release Data : 2019-11-13
Compound :
mol_id molecule chains synonym
1 Fusion protein of Beta-2 adrenergic receptor and T4 Lysozyme A Beta-2 adrenoreceptor,Beta-2 adrenoceptor,Lysis protein,Lysozyme,Muramidase
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: ADRB2, ADRB2R, B2AR
expression_system_common: Fall armyworm
expression_system_vector_type: baculovirus
Authors : Ishchenko, A., Stauch, B., Han, G.W., Batyuk, A., Shiriaeva, A., Li, C., Zatsepin, N.A., Weierstall, U., Liu, W., Nango, E., Nakane, T., Tanaka, R., Tono, K., Joti, Y., Iwata, S., Moraes, I., Gati, C., Cherezov, C.
Keywords : GPCR, COMPLEX-LCP method, SBDD, drug design, XFEL, LCP-SFX, Ligand Exchange, timolol, cavedilol, b2AR, beta2AR, MEMBRANE PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.5000 Å )
Citation :

Toward G protein-coupled receptor structure-based drug design using X-ray lasers.

Ishchenko, A.,Stauch, B.,Han, G.W.  et al.
(2019)  Iucrj  6 : 1106 - 1119

PubMed: 31709066
DOI: 10.1107/S2052252519013137

Reaction

Chain : A
UniProt : P07550 (ADRB2_HUMAN)
Reaction : -
Chain : A
UniProt : D9IEF7 (D9IEF7_BPT4)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. 3.2.1.17 ARBA:ARBA00000632, HAMAP-Rule:MF_04110, RuleBase:RU003788
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