Brand  (β version)

PDB ID: 6P25

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Ligands
Code Name Style Show Link
CPL 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine PoSSuM
NNM (3r)-3,31-dimethyl-7,11,15,19,23,27-hexamethylidenedotriacont-31-en-1-yl dihydrogen phosphate PoSSuM
Non-standard Residues
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Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 6P25   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structure of S. cerevisiae protein O-mannosyltransferase Pmt1-Pmt2 complex bound to the sugar donor and a peptide acceptor
Release Data : 2019-07-10
Compound :
mol_id molecule chains synonym
1 Dolichyl-phosphate-mannose--protein mannosyltransferase 1 A Pmt1
ec: 2.4.1.109
mol_id molecule chains synonym
2 Dolichyl-phosphate-mannose--protein mannosyltransferase 2 B Pmt2
ec: 2.4.1.109
mol_id molecule chains
3 acceptor peptide D
Source :
mol_id organism_scientific organism_common expression_system
1 Saccharomyces cerevisiae W303  (taxid:580240) Yeast Saccharomyces cerevisiae W303  (taxid:580240)
strain: W303
gene: PMT1, YDL095W, D2390
expression_system_common: Yeast
expression_system_strain: W303
mol_id organism_scientific organism_common expression_system
2 Saccharomyces cerevisiae W303  (taxid:580240) Yeast Saccharomyces cerevisiae W303  (taxid:580240)
strain: W303
gene: PMT2, FUN25, YAL023C
expression_system_common: Yeast
expression_system_strain: W303
mol_id organism_scientific organism_common
3 Saccharomyces cerevisiae W303  (taxid:580240) Yeast
synthetic: yes
Authors : Bai, L., Li, H.
Keywords : complex, TRANSFERASE, glycosylation
Exp. method : ELECTRON MICROSCOPY ( 3.2 Å )
Citation :

Structure of the eukaryotic protein O-mannosyltransferase Pmt1-Pmt2 complex.

Bai, L.,Kovach, A.,You, Q.  et al.
(2019)  Nat.Struct.Mol.Biol.  26 : 704 - 711

PubMed: 31285605
DOI: 10.1038/s41594-019-0262-6

Reaction

Chain : A
UniProt : P33775 (PMT1_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3- O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+) 2.4.1.109 PubMed:10764776, PubMed:8367478
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a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+) 2.4.1.109 PubMed:10764776, PubMed:8367478
-
Chain : B
UniProt : P31382 (PMT2_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3- O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+) 2.4.1.109 PubMed:8543034
-
a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+) 2.4.1.109 PubMed:8543034
-