Het-PDB Navi2 (PDB: 6OT0)

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Ligands
Code	Name		Style	Show	Link
CO1	17-[3-(3,3-dimethyl-oxiranyl)-1-methyl-propyl]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyc lopenta[a]phenanthren-3-ol				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 6OT0

Code :

6OT0 PDBj RCSB PDB PDBe

Header :

SIGNALING PROTEIN

Title :

Structure of human Smoothened-Gi complex

Release Data :

2019-06-12

Compound :

mol_id	molecule	chains	synonym
1	Smoothened homolog	R	SMO,Protein Gx
	fragment: residues 1-555

mol_id	molecule	chains	synonym
2	Guanine nucleotide-binding protein G(i) subunit alpha-1	A	Adenylate cyclase-inhibiting G alpha protein

mol_id	molecule	chains	synonym
3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	B	Transducin beta chain 1

mol_id	molecule	chains	synonym
4	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	G	G gamma-I

mol_id	molecule	chains
5	Fab light chain	L

mol_id	molecule	chains
6	Fab heavy chain	H

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Homo sapiens (taxid:9606)
	gene: SMO, SMOH expression_system_common: Human

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: GNAI1 expression_system_common: Fall armyworm

mol_id	organism_scientific	organism_common	expression_system
3	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: GNB1 expression_system_common: Fall armyworm

mol_id	organism_scientific	organism_common	expression_system
4	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: GNG2 expression_system_common: Fall armyworm

mol_id	organism_scientific	organism_common	expression_system
5	Mus musculus (taxid:10090)	Mouse	Escherichia coli (taxid:562)

mol_id	organism_scientific	organism_common	expression_system
6	Mus musculus (taxid:10090)	Mouse	Escherichia coli (taxid:562)

Authors :

Qi, X., Li, X.

Keywords :

GPCR, Complex, Hedgehog signaling, SIGNALING PROTEIN

Exp. method :

ELECTRON MICROSCOPY ( 3.84 Å )

Citation :

Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi.

Qi, X.,Liu, H.,Thompson, B. et al.
(2019) Nature 571 : 279 - 283

PubMed: 31168089
DOI: 10.1038/s41586-019-1286-0

Chain :	R
UniProt :	Q99835 (SMO_HUMAN)
Reaction :	-

Chain :

UniProt :

P63096 (GNAI1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
GTP + H2O = GDP + phosphate + H(+)	-	PubMed:33762731
GTP + H2O = GDP + phosphate + H(+)	left-to-right	PubMed:33762731

Chain :	B
UniProt :	P62873 (GBB1_HUMAN)
Reaction :	-

Chain :	G
UniProt :	P59768 (GBG2_HUMAN)
Reaction :	-

PDB ID: 6OT0

Hetero Atom Contents

Structure summary

Reaction