Brand  (β version)

PDB ID: 6OHU

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Ligands
Code Name Style Show Link
CTX (z)-2-[4-(1,2)-diphenyl-1-butenyl)-phenoxy]-N,N-dimethylethanamine PoSSuM
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Glycosylation
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Structure summary

Code : 6OHU   PDBj   RCSB PDB   PDBe
Header : membrane protein, isomerase/inhibitor
Title : Structure of EBP and tamoxifen
Release Data : 2019-06-19
Compound :
mol_id molecule chains synonym
1 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase A,B,C Cholestenol Delta-isomerase,Delta(8)-Delta(7) sterol isomerase,D8-D7 sterol isomerase,Emopamil-binding protein, EBP
ec: 5.3.3.5
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
gene: EBP
Authors : Long, T., Li, X.
Keywords : Membrane protein, Isomerase, isomerase-inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 3.526 Å )
Citation :

Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition.

Long, T.,Hassan, A.,Thompson, B.M.  et al.
(2019)  Nat Commun  10 : 2452 - 2452

PubMed: 31165728
DOI: 10.1038/s41467-019-10279-w

Reaction

Chain : A, B, C
UniProt : Q15125 (EBP_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
lathosterol = 5alpha-cholest-8-en-3beta-ol 5.3.3.5 PubMed:12760743, PubMed:8798407, PubMed:9894009
left-to-right PubMed:12760743, PubMed:8798407, PubMed:9894009
zymosterol = 5alpha-cholesta-7,24-dien-3beta-ol - PubMed:8798407, PubMed:9894009
left-to-right