Brand  (β version)

PDB ID: 6O81

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Ligands
Code Name Style Show Link
C7B 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 6O81   PDBj   RCSB PDB   PDBe
Header : TRANSLATION
Title : Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to translation initiation factor 2 from Homo sapiens
Release Data : 2019-05-15
Compound :
mol_id molecule chains synonym
1 Translation initiation factor eIF-2B subunit epsilon A,B eIF-2B GDP-GTP exchange factor subunit epsilon
mol_id molecule chains synonym
2 Translation initiation factor eIF-2B subunit beta C,D S20I15,S20III15,eIF-2B GDP-GTP exchange factor subunit beta
mol_id molecule chains synonym
3 Translation initiation factor eIF-2B subunit delta E,F eIF-2B GDP-GTP exchange factor subunit delta
mol_id molecule chains synonym
4 Translation initiation factor eIF-2B subunit alpha G,H eIF-2B GDP-GTP exchange factor subunit alpha
mol_id molecule chains synonym
5 Translation initiation factor eIF-2B subunit gamma I,J eIF-2B GDP-GTP exchange factor subunit gamma
mol_id molecule chains synonym
6 Eukaryotic translation initiation factor 2 subunit 1 L,M Eukaryotic translation initiation factor 2 subunit alpha,eIF-2alpha
mol_id molecule chains synonym
7 Eukaryotic translation initiation factor 2 subunit 3 S,T Eukaryotic translation initiation factor 2 subunit gamma X,eIF-2gX
mol_id molecule chains
8 Translation initiation factor eiF2 beta-subunit d,e
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: EIF2B5, EIF2BE
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: EIF2B2, EIF2BB
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: EIF2B4, EIF2BD
mol_id organism_scientific organism_common expression_system
4 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: EIF2B1, EIF2BA
mol_id organism_scientific organism_common expression_system
5 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: EIF2B3
mol_id organism_scientific organism_common expression_system
6 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: EIF2S1, EIF2A
mol_id organism_scientific organism_common expression_system
7 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: EIF2S3, EIF2G
mol_id organism_scientific organism_common expression_system
8 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
Authors : Nguyen, H., Kenner, L., Frost, A.
Keywords : Translation initiation, TRANSLATION
Exp. method : ELECTRON MICROSCOPY ( 3.21 Å )
Citation :

eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response.

Kenner, L.R.,Anand, A.A.,Nguyen, H.C.  et al.
(2019)  Science  364 : 491 - 495

PubMed: 31048491
DOI: 10.1126/science.aaw2922

Reaction

Chain : A, B
UniProt : Q13144 (EI2BE_HUMAN)
Reaction : -
Chain : C, D
UniProt : P49770 (EI2BB_HUMAN)
Reaction : -
Chain : E, F
UniProt : Q9UI10 (EI2BD_HUMAN)
Reaction : -
Chain : G, H
UniProt : Q14232 (EI2BA_HUMAN)
Reaction : -
Chain : I, J
UniProt : Q9NR50 (EI2BG_HUMAN)
Reaction : -
Chain : L, M
UniProt : P05198 (IF2A_HUMAN)
Reaction : -
Chain : S, T
UniProt : P41091 (IF2G_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + phosphate + H(+) 3.6.5.3 UniProtKB:P32481
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