Het-PDB Navi2 (PDB: 6O0O)

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Ligands
Code	Name		Style	Show	Link
F3Q	~{N}-(4-hydroxyphenyl)-3-[6-[[(3~{S})-3-(morpholin-4-ylmethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]-1,3-benzodioxol-5-yl]-~{N}-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide				PoSSuM

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Download interaction data: 6O0O

Code :

6O0O PDBj RCSB PDB PDBe

Header :

APOPTOSIS

Title :

crystal structure of BCL-2 G101V mutation with S55746

Release Data :

2019-05-22

Compound :

mol_id	molecule	chains	synonym
1	Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2	A,C	Bcl2-L-1,Apoptosis regulator Bcl-X
	mutation: G101V,G101V,G101V

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21 (taxid:511693)
	gene: BCL2 expression_system_strain: BL21

Authors :

Birkinshaw, R.W., Luo, C.S., Colman, P.M., Czabotar, P.E.

Keywords :

BCL-2, S55746, complex, Protein-protein interface inhibitor, resistance mutation, APOPTOSIS

Exp. method :

X-RAY DIFFRACTION ( 1.998 Å )

Citation :

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations.

Birkinshaw, R.W.,Gong, J.N.,Luo, C.S. et al.
(2019) Nat Commun 10 : 2385 - 2385

PDB ID: 6O0O