Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
0V4 (4r,5r,6r,6as,9s,9ae,10ar)-5-hydroxy-9-(methoxymethyl)-6,10a-dimethyl-3-(propan-2-yl)-1,2,4,5,6,6a,7,8,9,10a-decahydrodicyclopenta[a,D][8]annulen-4-yl alpha-D-glucopyranoside
CL Chloride ion
Modified Residues
Code Name Link
CSO S-hydroxycysteine
SEP Phosphoserine
Code : 6NV2   PDBj   RCSB PDB   PDBe
Header : PEPTIDE BINDING PROTEIN
Title : 14-3-3 sigma with RelA/p65 binding site pS45 in complex with DP005
Release Data : 2020-05-13
Compound :
mol_id molecule chains synonym
1 14-3-3 protein sigma A Epithelial cell marker protein 1,Stratifin
mol_id molecule chains
2 Transcription factor p65 P
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: SFN, HME1
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
synthetic: yes
Authors : Wolter, M., Ottmann, C.
Keywords : fusicoccanes, natural products, p65, 1433, PEPTIDE BINDING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.13 Å )
Citation :

Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products.

Wolter, M.,de Vink, P.,Neves, J.F.  et al.
(2020)  J.Am.Chem.Soc.  142 : 11772 - 11783

PubMed: 32501683
DOI: 10.1021/jacs.0c02151

Chain : A
UniProt : P31947 (1433S_HUMAN)
Reaction : -