Het-PDB Navi2 (PDB: 6NV2)

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Ligands
Code	Name		Style	Show	Link
CL	Chloride ion				PoSSuM
0V4	(4r,5r,6r,6as,9s,9ae,10ar)-5-hydroxy-9-(methoxymethyl)-6,10a-dimethyl-3-(propan-2-yl)-1,2,4,5,6,6a,7,8,9,10a-decahydrodicyclopenta[a,D][8]annulen-4-yl alpha-D-glucopyranoside				PoSSuM

Non-standard Residues
Code	Name	Show
CSO	S-hydroxycysteine
SEP	Phosphoserine

Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 6NV2

Code :

6NV2 PDBj RCSB PDB PDBe

Header :

PEPTIDE BINDING PROTEIN

Title :

14-3-3 sigma with RelA/p65 binding site pS45 in complex with DP005

Release Data :

2020-05-13

Compound :

mol_id	molecule	chains	synonym
1	14-3-3 protein sigma	A	Epithelial cell marker protein 1,Stratifin

mol_id	molecule	chains
2	Transcription factor p65	P

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: SFN, HME1

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes

Authors :

Wolter, M., Ottmann, C.

Keywords :

fusicoccanes, natural products, p65, 1433, PEPTIDE BINDING PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 1.13 Å )

Citation :

Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products.

Wolter, M.,de Vink, P.,Neves, J.F. et al.
(2020) J.Am.Chem.Soc. 142 : 11772 - 11783

PDB ID: 6NV2