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Ligands
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9CS (1r,2s,3s,4r,6s)-4,6-diamino-3-[(3-amino-3-deoxy-alpha-D-glucopyranosyl)oxy]-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside
MG Magnesium ion
Non-standard Residues
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Glycosylation
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Modification
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Code : 6NP5   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : AAC-VIa bound to Kanamycin B
Release Data : 2019-09-25
Compound :
mol_id molecule chains
1 Aminoglycoside N(3)-acetyltransferase A
ec: 2.3.1.81
Source :
mol_id organism_scientific expression_system
1 Enterobacter cloacae  (taxid:550) Escherichia coli BL21(DE3)  (taxid:469008)
gene: aac 3-VI
Authors : Kumar, P., Cuneo, M.J.
Keywords : Antibiotic modifying enzyme, substrate selectivity, ANTIBIOTIC, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.3530 Å )
Citation :

Low-Barrier and Canonical Hydrogen Bonds Modulate Activity and Specificity of a Catalytic Triad.

Kumar, P.,Agarwal, P.K.,Waddell, M.B.  et al.
(2019)  Angew.Chem.Int.Ed.Engl.  58 : 16260 - 16266

PubMed: 31515870
DOI: 10.1002/anie.201908535

Chain : A
UniProt : Q47030 (Q47030_ENTCL)
Reaction: EC: Evidence:
Physiological Direction:
a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')- acetyl-2-deoxystreptamine antibiotic + CoA + H(+) 2.3.1.81 ARBA:ARBA00001520, RuleBase:RU365031
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