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Ligands
Code Name Style Show Link
CL Chloride ion
CWB 1-methyl-N-[(1r,5s)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
BMA Beta-D-mannopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show
Code : 6NP0   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : Cryo-EM structure of 5HT3A receptor in presence of granisetron
Release Data : 2019-07-24
Compound :
mol_id molecule chains
1 5-hydroxytryptamine receptor 3A A,B,C,D,E
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Spodoptera frugiperda  (taxid:7108)
gene: Htr3a
expression_system_common: Fall armyworm
Authors : Basak, S., Chakrapani, S.
Keywords : MEMBRANE PROTEIN
Exp. method : ELECTRON MICROSCOPY ( 2.92 Å )
Citation :

Molecular mechanism of setron-mediated inhibition of full-length 5-HT3Areceptor.

Basak, S.,Gicheru, Y.,Kapoor, A.  et al.
(2019)  Nat Commun  10 : 3225 - 3225

PubMed: 31324772
DOI: 10.1038/s41467-019-11142-8

Chain : A, B, C, D, E
UniProt : E9QLC0 (5HT3A_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
Na(+)(in) = Na(+)(out) - UniProtKB:P46098
-
K(+)(in) = K(+)(out) - UniProtKB:P46098
-
Ca(2+)(in) = Ca(2+)(out) - UniProtKB:P46098
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Mg(2+)(in) = Mg(2+)(out) - UniProtKB:P46098
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