Het-PDB Navi2 (PDB: 6NNV)

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Ligands
Code	Name		Style	Show	Link

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
ACE	Acetyl group
NH2	Amino group

Download interaction data: 6NNV

Code :

6NNV PDBj RCSB PDB PDBe

Header :

IMMUNE SYSTEM

Title :

PD-L1 IgV domain complex with macro-cyclic peptide

Release Data :

2019-02-20

Compound :

mol_id	molecule	chains	synonym
1	Programmed cell death 1 ligand 1	A,B,C,D	Programmed death ligand 1,B7 homolog 1,B7-H1
	fragment: UNP residues 18-134

mol_id	molecule	chains
2	macrocyclic peptide	I,J,K,L

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli K-12 (taxid:83333)
	gene: CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1

mol_id	organism_scientific
2	Synthetic construct (taxid:32630)
	synthetic: yes

Authors :

Zhao, B., Perry, E.

Keywords :

Fragment-based screening, Structure-based design, PD-L1 inhibitor, Cancer drug discovery, Immunotherapy, IMMUNE SYSTEM

Exp. method :

X-RAY DIFFRACTION ( 1.920 Å )

Citation :

Fragment-based screening of programmed death ligand 1 (PD-L1).

Perry, E.,Mills, J.J.,Zhao, B. et al.
(2019) Bioorg. Med. Chem. Lett. 29 : 786 - 790

PDB ID: 6NNV