Het-PDB Navi2 (PDB: 6NFA)

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Ligands
Code	Name		Style	Show	Link
9K1	(2s)-2-{[3-(4-methylphenyl)imidazo[1,2-a]pyrazin-8-yl]amino}-3-(pyridin-3-yl)propan-1-ol				PoSSuM
ZN	Zinc ion				PoSSuM

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Download interaction data: 6NFA

Code :

6NFA PDBj RCSB PDB PDBe

Header :

SIGNALING PROTEIN/INHIBITOR

Title :

Vav1 inhibited by an allosteric inhibitor: Vav1 inhibitors block GEF activity

Release Data :

2019-12-25

Compound :

mol_id	molecule	chains	synonym
1	Proto-oncogene vav	A	Vav1 vav guanine nucleotide exchange factor 1
	fragment: UNP residues 170-575

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: VAV1, VAV

Authors :

Knapp, M.S., Elling, R.A., Ornelas, E.

Keywords :

GEF, Rac, Vav1, SIGNALING PROTEIN-INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.7000 Å )

Citation :

Allosteric Inhibitors of VAV1 Block Guanine Nucleotide Exchange Activity

Gerspacher, M.,Skaanderup, P.R.
To Be Published

PDB ID: 6NFA