Brand  (β version)

PDB ID: 6NF1

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Ligands
Code Name Style Show Link
9JY (2s)-3-[(3s)-1-(ethylsulfonyl)piperidin-3-yl]-2-{[3-(4-methylphenyl)imidazo[1,2-a]pyrazin-8-yl]amino}propan-1-ol PoSSuM
MES 2-(N-morpholino)-ethanesulfonic acid PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 6NF1   PDBj   RCSB PDB   PDBe
Header : METAL BINDING PROTEIN/INHIBITOR
Title : Vav1 inhibited by an allosteric inhibitor: Vav1 inhibitors block GEF activity
Release Data : 2019-12-25
Compound :
mol_id molecule chains
1 Proto-oncogene vav A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Unidentified baculovirus  (taxid:10469)
gene: VAV1, VAV
Authors : Knapp, M.S., Elling, R.A., Ornelas, E.
Keywords : GEF, Rac, Vav1, inhibitor, METAL BINDING PROTEIN-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.6000 Å )
Citation :

Allosteric Inhibitors of VAV1 Block Guanine Nucleotide Exchange Activity

Gerspacher, M.,Skaanderup, P.R.
To Be Published 

Reaction

Chain : A
UniProt : P15498 (VAV_HUMAN)
Reaction : -