Het-PDB Navi2 (PDB: 6MWE)

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Ligands
Code	Name		Style	Show	Link
SO4	Sulfate ion				PoSSuM
919	4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide				PoSSuM

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Download interaction data: 6MWE

Code :

6MWE PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

CRYSTAL STRUCTURE OF TIE2 IN COMPLEX WITH DECIPERA COMPOUND DP1919

Release Data :

2018-11-21

Compound :

mol_id	molecule	chains	synonym
1	Angiopoietin-1 receptor	A,B	Endothelial tyrosine kinase,Tunica interna endothelial cell kinase,Tyrosine kinase with Ig and EGF homology domains-2,Tyrosine-protein kinase receptor TEK,Tyrosine-protein kinase receptor TIE-2,hTIE2,p140 TEK
	ec: 2.7.10.1

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Trichoptera (taxid:30263)
	gene: TEK, TIE2, VMCM, VMCM1 expression_system_vector_type: plasmid expression_system_plasmid: VCID 2501

Authors :

Chun, L., Abendroth, J., Edwards, T.E.

Keywords :

TIE2, DP1919, EMERALDBIO, DECIPHERA, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.0500 Å )

Citation :

The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2

Harney, A.S.,Karagiannis, G.S.,Pignatelli, J. et al.
(2017) Mol. Cancer Ther. 16 : 2486 - 2501

Chain :

A, B

UniProt :

Q02763 (TIE2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.1	PROSITE-ProRule:PRU10028, PubMed:11513602, PubMed:12609966, PubMed:14665640, PubMed:15851516, PubMed:19223473, PubMed:8382358
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PDB ID: 6MWE