Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
919 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
SO4 Sulfate ion
Code : 6MWE
Header : TRANSFERASE
Title : CRYSTAL STRUCTURE OF TIE2 IN COMPLEX WITH DECIPERA COMPOUND DP1919
Release Data : 2018-11-21
Compound :
mol_id molecule chains synonym
1 Angiopoietin-1 receptor A,B Endothelial tyrosine kinase,Tunica interna endothelial cell kinase,Tyrosine kinase with Ig and EGF homology domains-2,Tyrosine-protein kinase receptor TEK,Tyrosine-protein kinase receptor TIE-2,hTIE2,p140 TEK
ec: 2.7.10.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Trichoptera  (taxid:30263)
gene: TEK, TIE2, VMCM, VMCM1
expression_system_vector_type: plasmid
expression_system_plasmid: VCID 2501
Authors : Chun, L., Abendroth, J., Edwards, T.E.
Keywords : TIE2, DP1919, EMERALDBIO, DECIPHERA, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.0500 Å )
Citation :

The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2

Harney, A.S.,Karagiannis, G.S.,Pignatelli, J.  et al.
(2017)  Mol. Cancer Ther.  16 : 2486 - 2501

PubMed: 28838996
DOI: 10.1158/1535-7163.MCT-17-0241

Chain : A, B
UniProt : Q02763 (TIE2_HUMAN)
Reaction : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.