Het-PDB Navi2 (PDB: 6MU7)

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Ligands
Code	Name		Style	Show	Link
JYY	4-{3-[{4-[(R)-cyano(phenyl)methyl]piperidin-1-yl}(oxo)acetyl]-4-methoxy-1h-pyrrolo[2,3-C]pyridin-7-yl}-N-(2-hydroxyethyl)-1,3-thiazole-2-carboxamide				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize
BMA	Beta-D-mannopyranose
MAN	Alpha-D-mannopyranose
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose

Modification
Code	Name	Show

Download interaction data: 6MU7

Code :

6MU7 PDBj RCSB PDB PDBe

Header :

IMMUNE SYSTEM/INHIBITOR

Title :

Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-818251 in Complex with Human Antibodies 3H109L and 35O22 at 3.1 Angstrom

Release Data :

2019-01-16

Compound :

mol_id	molecule	chains	synonym
1	Envelope glycoprotein gp160	B	Env polyprotein
	fragment: gp41 mutation: I559P, A605C

mol_id	molecule	chains
2	35O22 scFv heavy chain portion	D
	mutation: E10T, L11T, K12T, A16S, I68N, K83T, F84S,

mol_id	molecule	chains
3	35O22 scFv light chain portion	E

mol_id	molecule	chains	synonym
4	Envelope glycoprotein gp160	G	Env polyprotein
	fragment: gp120 mutation: N137A

mol_id	molecule	chains
5	3H109L Fab heavy chain	H

mol_id	molecule	chains
6	3H109L Fab light chain	L
	mutation: E184M, S188M

Source :

mol_id	organism_scientific	expression_system
1	Human immunodeficiency virus 1 (taxid:11676)	Homo sapiens (taxid:9606)
	gene: env expression_system_common: Human

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Homo sapiens (taxid:9606)
	expression_system_common: Human

mol_id	organism_scientific	organism_common	expression_system
3	Homo sapiens (taxid:9606)	Human	Homo sapiens (taxid:9606)
	expression_system_common: Human

mol_id	organism_scientific	expression_system
4	Human immunodeficiency virus 1 (taxid:11676)	Homo sapiens (taxid:9606)
	gene: env expression_system_common: Human

mol_id	organism_scientific	organism_common	expression_system
5	Homo sapiens (taxid:9606)	Human	Homo sapiens (taxid:9606)
	expression_system_common: Human

mol_id	organism_scientific	expression_system
6	Homo sapiens (taxid:9606)	Homo sapiens (taxid:9606)

Authors :

Lai, Y.-T., Kwong, P.D.

Keywords :

HIV-1 Envelope Prefusion Trimer, Entry Inhibitors, IMMUNE SYSTEM-INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.5010 Å )

Citation :

Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry.

Lai, Y.T.,Wang, T.,O'Dell, S. et al.
(2019) Nat Commun 10 : 47 - 47

PubMed: 30604750
DOI: 10.1038/s41467-018-07851-1

Chain :	G
UniProt :	Q2N0S6 (Q2N0S6_HV1)
Reaction :	-

PDB ID: 6MU7

Hetero Atom Contents

Structure summary

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