Brand  (β version)

PDB ID: 6MU5

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Ligands
Code Name Style Show Link
SO4 Sulfate ion PoSSuM
Non-standard Residues
Code Name Show
FA2 5-(6-amino-9h-purin-9-yl)-4-hydroxytetrahydrofuran-3-yl dihydrogen phosphate
TC 4-azanyl-1-[(2~{R},3~{R},4~{S})-3-oxidanyl-4-[oxidanyl-bis(oxidanylidene)-$L^{6}-phosphanyl]oxy-oxolan-2-yl]pyrimidin-2-one
TFT (L)-alpha-threofuranosyl-thymine-3'-monophosphate
TG 2-azanyl-9-[(2~{R},3~{R},4~{S})-3-oxidanyl-4-[oxidanyl-bis(oxidanylidene)-$L^{6}-phosphanyl]oxy-oxolan-2-yl]-1~{H}-purin-6-one
Glycosylation
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Modification
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Structure summary

Code : 6MU5   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/DNA
Title : Bst DNA polymerase I TNA/DNA binary complex
Release Data : 2019-06-05
Compound :
mol_id molecule chains
1 DNA (5'-D(P*GP*CP*GP*AP*TP*CP*AP*CP*GP*T)-3') P
mol_id molecule chains synonym
2 DNA polymerase I A Bst DNA polymerase I
ec: 2.7.7.7
mol_id molecule chains
3 TNA (5'-D(P*(TG)P*(TFT)P*(FA2)P*(TC)P*(TG)P*(TFT)P*(TG)P*(FA2)P*(TFT)P*(TC)P*(TG)P*(TC)P*(FA2))-3') T
Source :
mol_id organism_scientific
1 Synthetic construct  (taxid:32630)
synthetic: yes
mol_id organism_scientific expression_system
2 Geobacillus stearothermophilus  (taxid:1422) Escherichia coli  (taxid:562)
gene: polA
mol_id organism_scientific
3 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Jackson, L.N., Chim, N., Chaput, J.C.
Keywords : XNA reverse transcription, TRANSFERASE-DNA complex
Exp. method : X-RAY DIFFRACTION ( 1.912 Å )
Citation :

Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase.

Jackson, L.N.,Chim, N.,Shi, C.  et al.
(2019)  Nucleic Acids Res.  47 : 6973 - 6983

PubMed: 31170294
DOI: 10.1093/nar/gkz513

Reaction

Chain : A
UniProt : E1C9K5 (E1C9K5_GEOSE)
Reaction: EC: Evidence:
Physiological Direction:
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 ARBA:ARBA00024632, RuleBase:RU004460
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