PDB ID: 6MQ3
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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J22 | {(8r,9s,10s)-9-(2',3'-dimethyl[1,1'-biphenyl]-4-yl)-6-[(1-methyl-1h-imidazol-2-yl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl}methanol | PoSSuM | |||
EPE | 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid | PoSSuM |
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Download interaction data: 6MQ3
Structure summary
Code : | 6MQ3 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE/HYDROLASE INHIBITOR | ||||||||||||
Title : | Structure of Cysteine-free Human Insulin-Degrading Enzyme in complex with Substrate-selective Macrocycle Inhibitor 63 | ||||||||||||
Release Data : | 2019-04-03 | ||||||||||||
Compound : |
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Authors : | Tan, G.A., Seeliger, M.A., Welsh, A.J., Maianti, J.P., Liu, D.R. | ||||||||||||
Keywords : | Insulin, Glucagon, Diabetes, Exo-site, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 3.56914708689 Å ) | ||||||||||||
Citation : |
Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme.
Maianti, J.P.,Tan, G.A.,Vetere, A.
et al.
PubMed: 31086331 Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones.
Maianti, J.P.,McFedries, A.,Foda, Z.H.
et al.
PubMed: 24847884 |
Reaction
Chain : | A, B | ||||||||
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UniProt : | P14735 (IDE_HUMAN) | ||||||||
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