PDB ID: 6MOA
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Structure summary
Code : | 6MOA PDBj RCSB PDB PDBe | ||||||||||||
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Header : | transcription/transcription inhibitor | ||||||||||||
Title : | C-terminal bromodomain of human BRD2 in complex with 4-(2-cyclopropyl-7-(6-methylquinolin-5-yl)-1H-benzo[D]imidazol-5-yl)-3,5-dimethylisoxazole inhibitor | ||||||||||||
Release Data : | 2019-01-23 | ||||||||||||
Compound : |
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Source : |
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Authors : | Lansdon, E.B., Newby, Z.E.R. | ||||||||||||
Keywords : | Inhibitor, epigenetic reader, bromodomain, transcription-transcription inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.271 Å ) | ||||||||||||
Citation : |
Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
Sperandio, D.,Aktoudianakis, V.,Babaoglu, K.
et al.
PubMed: 30606676 |
Reaction
Chain : | A |
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UniProt : | P25440 (BRD2_HUMAN) |
Reaction : | - |