Het-PDB Navi2 (PDB: 6MNY)

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Ligands
Code	Name		Style	Show	Link
JVP	5-amino-1-[(3r)-1-cyanopiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]-1h-pyrazole-4-carboxamide				PoSSuM

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Download interaction data: 6MNY

Code :

6MNY PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of mouse BTK kinase domain in complex with compound 9a

Release Data :

2019-01-30

Compound :

mol_id	molecule	chains
1	Tyrosine-protein kinase	A,B
	ec: 2.7.10.2 fragment: Protein kinase domain, residues 384-659

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Mus musculus (taxid:10090)	Mouse	Spodoptera frugiperda (taxid:7108)
	gene: Btk expression_system_common: Fall armyworm

Authors :

Han, S., Caspers, N., Ohren, J.O.

Keywords :

kinase, drug design, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.80 Å )

Citation :

Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning.

Schnute, M.E.,Benoit, S.E.,Buchler, I.P. et al.
(2019) ACS Med Chem Lett 10 : 80 - 85

Chain :

A, B

UniProt :

Q7TMU1 (Q7TMU1_MOUSE)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)	2.7.10.2	ARBA:ARBA00051245, RuleBase:RU362096
	-	ARBA:ARBA00051245, RuleBase:RU362096
Cofactor:	Evidence:	Note:
Zn(2+)	ECO:0000256 \| ARBA:ARBA00001947	-

PDB ID: 6MNY