Brand  (β version)

PDB ID: 6MLS

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Ligands
Code Name Style Show Link
0JO 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid PoSSuM
CQG Pyridin-4-ol PoSSuM
K Potassium ion PoSSuM
P33 3,6,9,12,15,18-hexaoxaicosane-1,20-diol PoSSuM
Non-standard Residues
Code Name Show
LLP (2s)-2-amino-6-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]hexanoic acid
Glycosylation
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Modification
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Structure summary

Code : 6MLS   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Citrobacter freundii tyrosine phenol-lyase complexed with 4-hydroxypyridine and aminoacrylate from L-tyrosine
Release Data : 2019-10-02
Compound :
mol_id molecule chains synonym
1 Tyrosine phenol-lyase A Beta-tyrosinase
ec: 4.1.99.2
mol_id molecule chains synonym
2 Tyrosine phenol-lyase B Beta-tyrosinase
ec: 4.1.99.2
Source :
mol_id organism_scientific expression_system
1 Citrobacter freundii  (taxid:546) Escherichia coli BL21(DE3)  (taxid:469008)
atcc: 29063
gene: tpl
expression_system_strain: BL21(DE3)
expression_system_plasmid: pLATE11-TPL
mol_id organism_scientific expression_system
2 Citrobacter freundii  (taxid:546) Escherichia coli BL21(DE3)  (taxid:469008)
atcc: 29063
gene: tpl
expression_system_strain: BL21(DE3)
expression_system_plasmid: pLATE11-TPL
Authors : Phillips, R.S.
Keywords : pyridoxal-5'-phosphate, aminotransferase fold, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.7700 Å )
Citation :

Pressure and Temperature Effects on the Formation of Aminoacrylate Intermediates of Tyrosine Phenol-lyase Demonstrate Reaction Dynamics

Phillips, R.S.,Craig, S.,Kovalevsky, A.  et al.
(2020)  Acs Catalysis  10 : 1692 - 1703

DOI: 10.1021/acscatal.9b03967

Reaction

Chain : B
UniProt : P31013 (TPL_CITFR)
Reaction: EC: Evidence:
Physiological Direction:
L-tyrosine + H2O = phenol + pyruvate + NH4(+) 4.1.99.2 -
-
Cofactor: Evidence: Note:
pyridoxal 5'-phosphate - -