Brand  (β version)

PDB ID: 6MJY

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Ligands
Code Name Style Show Link
CPR 6-chloropurine riboside, 5'-monophosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6MJY   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE/OXIDOREDUCTASE inhibitor
Title : M. thermoresistible GuaB2 delta-CBS in complex with 6Cl-IMP
Release Data : 2019-09-25
Compound :
mol_id molecule chains synonym
1 Inosine-5'-monophosphate dehydrogenase A IMPDH
ec: 1.1.1.205,1.1.1.205
Source :
mol_id organism_scientific expression_system
1 Mycobacterium thermoresistibile  (taxid:1797) Escherichia coli  (taxid:562)
gene: guaB, RMCT_0580
Authors : Ascher, D.B., Pacitto, A., Blundell, T.L.
Keywords : Complex, Fragment, IMPDH, OXIDOREDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.560 Å )
Citation :

Covalent inactivation of Mycobacterium thermoresistibile inosine-5'-monophosphate dehydrogenase (IMPDH).

Trapero, A.,Pacitto, A.,Chan, D.S.  et al.
(2020)  Bioorg.Med.Chem.Lett.  30 : 126792 - 126792

PubMed: 31757668
DOI: 10.1016/j.bmcl.2019.126792

Reaction

Chain : A
UniProt : A0A100XBM0 (A0A100XBM0_MYCTH)
Reaction: EC: Evidence:
Physiological Direction:
H2O + IMP + NAD(+) = H(+) + NADH + XMP 1.1.1.205 ARBA:ARBA00024264, HAMAP-Rule:MF_01964, RuleBase:RU003928
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