PDB ID: 6MJW
Hetero Atom Contents
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JUJ | 1-[9-(6-aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydro-2h-pyrido[4,3-B]indol-2-yl]-2-hydroxyethan-1-one | PoSSuM | |||
ZN | Zinc ion | PoSSuM |
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Download interaction data: 6MJW
Structure summary
Code : | 6MJW PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE/TRANSFERASE INHIBITOR | ||||||||||||
Title : | human cGAS catalytic domain bound with the inhibitor G150 | ||||||||||||
Release Data : | 2019-05-29 | ||||||||||||
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Authors : | Lama, L., Adura, C., Xie, W., Tomita, D., Kamei, T., Kuryavyi, V., Gogakos, T., Steinberg, J.I., Miller, M., Ramos-Espiritu, L., Asano, Y., Hashizume, S., Aida, J., Imaeda, T., Okamoto, R., Jennings, A.J., Michinom, M., Kuroita, T., Stamford, A., Gao, P., Meinke, P., Glickman, J.F., Patel, D.J., Tuschl, T. | ||||||||||||
Keywords : | human cGAS, DNA sensor, inhibitor, IMMUNE SYSTEM, TRANSFERASE-TRANSFERASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.405 Å ) | ||||||||||||
Citation : |
Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression.
Lama, L.,Adura, C.,Xie, W.
et al.
PubMed: 31113940 |
Reaction
Chain : | A | |||||||||
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UniProt : | Q8N884 (CGAS_HUMAN) | |||||||||
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