Brand  (β version)

PDB ID: 6MJI

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Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
JTD N-[(2s,3s,4r)-1-{[4-O-(cyclopropylmethyl)-alpha-D-galactopyranosyl]oxy}-3,4-dihydroxyoctadecan-2-yl]hexacosanamide PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
BMA Beta-D-mannopyranose
FUC Alpha-L-fucopyranose
MAN Alpha-D-mannopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 6MJI   PDBj   RCSB PDB   PDBe
Header : IMMUNE SYSTEM
Title : Crystal structure of the mCD1d/xxs (JJ304) /iNKTCR ternary complex
Release Data : 2019-01-09
Compound :
mol_id molecule chains synonym
1 T cell receptor alpha variable 11,T cell receptor alpha joining 18,Human nkt tcr alpha chain, CHIMERIC PROTEIN C T cell receptor alpha variable 11D, Human nkt tcr beta chain
mol_id molecule chains
2 Beta-chain,Tcell receptor chain,T cell receptor beta constant 2 D
mol_id molecule chains synonym
3 Antigen-presenting glycoprotein CD1d1 A MCG3074,isoform CRA_a
mol_id molecule chains
4 Beta-2-microglobulin B
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: B2M, HDCMA22P
expression_system_strain: BL21(DE3)
expression_system_plasmid: pET22b+
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: TRBC2, TCRBC2
expression_system_strain: BL21(DE3)
mol_id organism_scientific organism_common expression_system
3 Mus musculus  (taxid:10090) Mouse Spodoptera frugiperda  (taxid:7108)
gene: Cd1d1, mCG_3074
expression_system_cell_line: SF9
expression_system_vector_type: transfer vector
expression_system_plasmid: pBACpHp10
mol_id organism_scientific organism_common expression_system
4 Mus musculus  (taxid:10090) Mouse Spodoptera frugiperda  (taxid:7108)
gene: B2m
expression_system_cell_line: SF9
expression_system_vector_type: transfer vector
expression_system_plasmid: pBACp10pH
Authors : Zajonc, D.M., Bitra, A., Janssens, J.
Keywords : MHC-fold, Ig-fold, glycolipid antigen presentation, T cell receptor, IMMUNE SYSTEM
Exp. method : X-RAY DIFFRACTION ( 2.3000 Å )
Citation :

4"-O-Alkylated alpha-Galactosylceramide Analogues as iNKT-Cell Antigens: Synthetic, Biological, and Structural Studies.

Janssens, J.,Bitra, A.,Wang, J.  et al.
(2019)  ChemMedChem  14 : 147 - 168

PubMed: 30556652
DOI: 10.1002/cmdc.201800649

Reaction

Chain : C
UniProt : A0A0B4J1J9 (A0A0B4J1J9_MOUSE)
Reaction : -
Chain : C
UniProt : K7N5M3 (K7N5M3_HUMAN)
Reaction : -
Chain : D
UniProt : A2NTY6 (A2NTY6_MOUSE)
Reaction : -
Chain : D
UniProt : A0N8J3 (A0N8J3_MOUSE)
Reaction : -
Chain : D
UniProt : A0A5B9 (TRBC2_HUMAN)
Reaction : -
Chain : A
UniProt : A0A0R4J090 (A0A0R4J090_MOUSE)
Reaction : -
Chain : B
UniProt : P01887 (B2MG_MOUSE)
Reaction : -