Brand  (β version)

PDB ID: 6MIG

Hetero Atom Contents

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Ligands
Code Name Style Show Link
Non-standard Residues
Code Name Show
1W5 (1r)-1-(6-amino-2-hydroxy-5-nitropyridin-3-yl)-1,4-anhydro-2-deoxy-5-O-phosphono-D-erythro-pentitol
1WA 2-amino-8-(2-deoxy-5-O-phosphono-beta-D-erythro-pentofuranosyl)-4-hydroxy-1h-imidazo[1,2-a][1,3,5]triazine-5,8-diium
IGU 2'-deoxyisoguanine-5'-monophosphate
JSP (1r)-1-(4-amino-1-methyl-2-oxo-1,2-dihydropyrimidin-5-yl)-1,4-anhydro-2-deoxy-5-O-phosphono-D-erythro-pentitol
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 6MIG   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/DNA
Title : Crystal structure of host-guest complex with PB hachimoji DNA
Release Data : 2019-02-27
Compound :
mol_id molecule chains synonym
1 Gag-Pol polyprotein A Pr180gag-pol
ec: 3.4.23.-,2.7.7.49,2.7.7.7,3.1.26.4,2.7.7.-,3.1.-.-
mol_id molecule chains
2 DNA (5'-D(*CP*TP*TP*AP*TP*(1WA)P*(1WA)P*(DS))-3') B
mol_id molecule chains
3 DNA (5'-D(P*(DB)P*(1W5)P*(1W5)P*AP*TP*AP*AP*G)-3') G
Source :
mol_id organism_scientific organism_common expression_system
1 Moloney murine leukemia virus (isolate Shinnick)  (taxid:928306) MoMLV Escherichia coli  (taxid:562)
strain: isolate Shinnick
gene: gag-pol
mol_id organism_scientific
2 Synthetic construct  (taxid:32630)
synthetic: yes
mol_id organism_scientific
3 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Georgiadis, M.M.
Keywords : Host-guest complex, hachimoji DNA, N-terminal fragment of MMLV RT, DNA, HYDROLASE-DNA complex
Exp. method : X-RAY DIFFRACTION ( 1.7000 Å )
Citation :

Hachimoji DNA and RNA: A genetic system with eight building blocks.

Hoshika, S.,Leal, N.A.,Kim, M.J.  et al.
(2019)  Science  363 : 884 - 887

PubMed: 30792304
DOI: 10.1126/science.aat0971

Reaction

Chain : A
UniProt : P03355 (POL_MLVMS)
Reaction: EC: Evidence:
Physiological Direction:
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.49 PROSITE- ProRule:PRU00405
-
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 PROSITE- ProRule:PRU00405
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Endonucleolytic cleavage to 5'-phosphomonoester. 3.1.26.4 PROSITE-ProRule:PRU00408
-