Brand  (β version)

PDB ID: 6ME2

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Ligands
Code Name Style Show Link
JEV N-{2-[(8s)-1,6,7,8-tetrahydro-2h-indeno[5,4-B]furan-8-yl]ethyl}propanamide PoSSuM
OLA Oleic acid PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
Non-standard Residues
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YCM S-(2-amino-2-oxoethyl)-L-cysteine
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Structure summary

Code : 6ME2   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : XFEL crystal structure of human melatonin receptor MT1 in complex with ramelteon
Release Data : 2019-04-24
Compound :
mol_id molecule chains synonym
1 chimera protein of Melatonin receptor type 1A and GlgA glycogen synthase A Mel1a receptor,Glycogen synthase,Mel1a receptor
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
strain: GE5 / Orsay
gene: MTNR1A
expression_system_common: Fall armyworm
expression_system_vector_type: baculovirus
Authors : Stauch, B., Johansson, L.C., McCorvy, J.D., Patel, N., Han, G.W., Gati, C., Batyuk, A., Ishchenko, A., Brehm, W., White, T.A., Michaelian, N., Madsen, C., Zhu, L., Grant, T.D., Grandner, J.M., Olsen, R.H.J., Tribo, A.R., Weierstall, U., Roth, B.L., Katritch, V., Liu, W., Cherezov, V.
Keywords : GPCR, melatonin receptor type 1A (MT1), membrane protein, ramelteon, XFEL, LCP, PGS, circadian rhythm, jetlag
Exp. method : X-RAY DIFFRACTION ( 2.80 Å )
Citation :

Structural basis of ligand recognition at the human MT1melatonin receptor.

Stauch, B.,Johansson, L.C.,McCorvy, J.D.  et al.
(2019)  Nature  569 : 284 - 288

PubMed: 31019306
DOI: 10.1038/s41586-019-1141-3

Reaction

Chain : A
UniProt : P48039 (MTR1A_HUMAN)
Reaction : -
Chain : A
UniProt : Q9V2J8 (Q9V2J8_PYRAB)
Reaction : -