Het-PDB Navi2 (PDB: 6MDA)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
JED	3-(4-bromophenyl)-6-(4-methylphenyl)-1h-pyrazolo[3,4-B]pyridine-4-carboxylic acid				PoSSuM
PO4	Phosphate ion				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 6MDA

Code :

6MDA PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrazolo-pyridine 4

Release Data :

2019-02-13

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein phosphatase non-receptor type 11	A,B	Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,Shp2,SH-PTP3
	ec: 3.1.3.48

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: PTPN11, PTP2C, SHPTP2

Authors :

Fodor, M., Stams, T.

Keywords :

SHP2, PTPN11, PROTEIN TYROSINE PHOSPHATASE, PHOSPHATASE, ALLOSTERIC INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.21 Å )

Citation :

Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors.

Bagdanoff, J.T.,Chen, Z.,Acker, M. et al.
(2019) J. Med. Chem. 62 : 1781 - 1792

Chain :

A, B

UniProt :

Q06124 (PTN11_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate	3.1.3.48	PROSITE-ProRule:PRU10044, PubMed:20170098, PubMed:26742426, PubMed:28074573
	-

PDB ID: 6MDA