Brand  (β version)

PDB ID: 6MD8

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
J84 1-(2,4-dichlorophenyl)-4-(1h-tetrazol-5-yl)-1h-pyrazol-5-amine PoSSuM
DMS Dimethyl sulfoxide PoSSuM
Non-standard Residues
Code Name Show
PCA Pyroglutamic acid
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 6MD8   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/INHIBITOR
Title : Crystal structure of CTX-M-14 with compound 3
Release Data : 2019-04-17
Compound :
mol_id molecule chains
1 Beta-lactamase CTX-M-14 A,B
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: blaCTX-M-14
Authors : Akhtar, A., Chen, Y.
Keywords : Tetrazole, inhibitor, complex, Extended spectrum beta-lactamase, HYDROLASE, HYDROLASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.40 Å )
Citation :

Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery.

Torelli, N.J.,Akhtar, A.,DeFrees, K.  et al.
(2019)  Acs Infect Dis.  5 : 1013 - 1021

PubMed: 30942078
DOI: 10.1021/acsinfecdis.9b00052

Reaction

Chain : A, B
UniProt : A0A2S1PK93 (A0A2S1PK93_ECOLX)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 ARBA:ARBA00001526, RuleBase:RU361140
-