PDB ID: 6MBP
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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EDO | 1,2-ethanediol | PoSSuM | |||
JDG | 2-cyclohexyl-7-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-8-[3-(pyrrolidin-1-yl)propoxy]-3h-1,4-benzodiazepin-5-amine | PoSSuM | |||
SAH | S-adenosyl-L-homocysteine | PoSSuM | |||
ZN | Zinc ion | PoSSuM |
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Download interaction data: 6MBP
Structure summary
Code : | 6MBP PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE/TRANSFERASE INHBITOR | ||||||||||||
Title : | GLP Methyltransferase with Inhibitor EML741- P3121 Crystal Form | ||||||||||||
Release Data : | 2019-02-27 | ||||||||||||
Compound : |
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Authors : | Horton, J.R., Cheng, X. | ||||||||||||
Keywords : | Histone, H3, Methylation Inhibition, TRANSFERASE, TRANSFERASE-TRANSFERASE INHBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.947 Å ) | ||||||||||||
Citation : |
Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure.
Milite, C.,Feoli, A.,Horton, J.R.
et al.
PubMed: 30753076 |
Reaction
Chain : | A, B | ||||||||||||
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UniProt : | Q9H9B1 (EHMT1_HUMAN) | ||||||||||||
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